Endocrine Abstracts

Just before the turning of the 20th century a detailed series of connected events led to the understanding of the physiology, pathophysiology, chemical synthesis, cellular and molecular biology, and pharmacological use of parathyroid hormone (PTH) in the next 120 years. Thanks to scientists like Fuller Albright, Gerald D. Aurbach, John T. Potts, Karen K. Winer, Thomas J. Gardella, and many others, huge progress has been made over the decades through biotechnological advances t...

35-year-old lady, has a background of Hypertension, oophorectomies for ovarian cancer and previous 2 IVF attempts, referred to endocrinology with three-week history of blurred vision, bitemporal hemianopia and large pituitary mass on MRI Upon assessment, she reported visual disturbance and intermittent headache. She has no periods which is expected with the history of oophorectomy, but she denied galactorrhoea or any symptoms suggestive of pituitary hormone excess or deficienc...

History: 72 yr. Female, Initially presented to A&E with new confusion and speech disturbance. NEWS of 7- RR 22, sats- 98% on RA, BP 162/107, HR-124, and T- 37. AMTS- 7/10. PMH: depression, previous dysphasia, Medication: Amitriptyline, Omeprazole.Investigations: FBC, UE, LFT, CRP, Cholesterol levels, urine dip Normal and CT head – normal. ECG – Sinus tachycardia. Observations improved and no obvious cause found for confusion patient was dis...

Case summary: A 40 year-old lady, who has a background of asthma, presented to emergency department with back pain radiated down to her left leg with associated foot drop. She also complained of 2 months history of weight gain, hirsutism, and menstrual disturbance. Clinical examination confirmed that she had some cushingoid features. Further assessment and investigations revealed that she had acute disc prolapse on MRI as well as an incidental finding of right adrenal gland an...

Introduction: Hypercalcemia has been described in patients with granulomatous disorders. Most commonly sarcoidosis (10% of patients) and tuberculosis with three-fold increase in hypercalciuria. It’s due to production of calcidiol from calcitriol in the lung and lymph nodes that is independent of PTH. Main modalities of therapy are low-calcium diet, glucocorticoids, and treatment of the underlying disease.The Case: A 48-year-old male, referred to end...

Background: Hypothyroidism is a common disorder presenting with both somatic and psychiatric symptoms. Two cases of late onset psychosis are presented as an initial manifestation of myxedema.Case presentation: 1. An 80-year old woman who had no past medical history presented with auditory and persecutory hallucinations. During her hospital stay she was found to have a decreased level of consciousness (GCS:4), and a blood investigation showed the presence...

Immunotherapy with immune checkpoint inhibitors has become an effective treatment of many malignancies resistant to conventional chemotherapies. Immune checkpoints are molecules on the surface of immune cells involved in the regulation of the immune response and immune checkpoint inhibitors are monoclonal antibodies directed against certain immune checkpoints, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death 1 (PD-1) and its ligand (PD-L1), res...

Our group studies the influence of different endocrine factors on cardiovascular function. Ang II is the main vasopeptide of Renin-Angiotensin System (RAS) and exerts its potent biological effects through AT1 and AT2 receptors. In heart, Ang II induces cardiomyocyte hypertrophy and fibroblast hyperplasia through TGF-β1 recruitment. On the other hand, cardiovascular system is very sensitive to the action of the Thyroid Hormones (THs). One major cardiovascular manifestation...

Rare skeletal metabolic diseases comprise a group of diseases commonly associated with severe clinical consequences. In recent years, the description of the clinical phenotypes and radiographic features of several genetic bone disorders was paralleled by the discovery of key molecular pathways involved in the regulation of bone and mineral metabolism. Including this information in the description and classification of rare skeletal diseases may improve the recognition and mana...

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